Catabolic factors in tumour-induced cachexia.

by Susan Anne Beck

Publisher: Aston University. Department of Pharmaceutical Sciences in Birmingham

Written in English
Published: Downloads: 931
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Edition Notes

Thesis (PhD) - Aston University, 1989.

ID Numbers
Open LibraryOL13876042M

Catabolic factors in tumour-induced cachexia. by Susan Anne Beck Download PDF EPUB FB2

However, the factors involved in the etiology of cachexia (proinflammatory cytokines, hypermetabolism and malnutrition) are very different from those behind sarcopenia (hormonal changes, physical. Factors like recent chemotherapy, surgery, or cachexia do not seem to attenuate the anabolic potential to feeding.

Summary: Cancer patients have a. The traditional view of cancer cachexia is summarised in Figure the s, cachexia was generally thought of as the result of an energy deficiency caused by the combination of increased energy consumption by the tumour and decreased energy intake due to tumour-related factors that acted on the satiety centre of the central nervous by: Patients with peritoneal metastasis (PM) of gastrointestinal and gynecological origin present with a nutritional deficit characterized by increased resting energy expenditure (REE), loss of muscle mass, and protein catabolism.

Progression of peritoneal metastasis, as with other advanced malignancies, is associated with cancer cachexia anorexia syndrome (CAS), involving poor Author: Rami Archid, Wiebke Solass, Clemens Tempfer, Alfred Königsrainer, Michael Adolph, Marc A.

Reymond, R. Cancer-associated cachexia (cancer cachexia) is a major contributor to the modality and mortality of a wide variety of solid tumors. It is estimated that cachexia inflicts approximately ~60% of all cancer patients and is the immediate cause of ~30% of all cancer-related death.

However, there is no established treatment of this disorder due to the poor understanding of its underlying : Thomas K Sin, Guohua Zhang, Zicheng Zhang, Song Gao, Min Li, Yi-Ping Li. Catabolic factors in tumour-induced cachexia. PHD thesis, Aston University. Behseta, Farshid ().

Deformation and failure of welded steels used in offshore constructions. PHD thesis, Aston University. Bendjeddou, Nadia (). The development of a new compiler-compiler front-end. PHD thesis, Aston University. Booth, David J. The term sarcopenia refers to the loss of muscle mass that occurs with ageing.

On the basis of study results showing that muscle mass is only moderately related to functional outcomes, international working groups have proposed that loss of muscle strength or physical function should also be included in the definition. Irrespective of how sarcopenia is defined, both low Cited by: Tumour-induced inflammation can lead to increased production of tumour necrosis factor alpha, interleukin 6, interferon gamma, and other cytokines, which results in increased protein catabolism, decreased protein anabolism, insulin resistance, and lipolysis.

Although decreased caloric intake and anorexia associated with cancer might Cited by: Abstract. Anorexia-cachexia syndrome [] and lipodystrophy [] [] are two conditions frequently associated with the course of HIV many circumstances, they can be included as components of a single disease, multifactorial in origin, leading to alterations of energetic metabolism and to body fat tissue by: 1.

Among the chronic illnesses causing cachexia are chronic heart failure (CHF), chronic obstructive pulmonary disease (COPD), and cancer. The causes of cachexia in CHF appear to be elevations in TNF-a, IL-6, norepinephrine, epi-nephrine, and cortisol. Furthermore, anabolic stimuli, such as IGF-1 and DHEA, are reduced in CHF patients /5.

Inthe International Association of Athletics Federations (IAAF) and IOC introduced a ‘hyperandrogenism’ rule that excluded women with a serum testosterone >10 nmol/L from participating in elite sport. This rule was based on the false premise that the greater lean body mass in men was a consequence of their higher serum testosterone.

This rule did not Cited by: 7. A reduction in serum calcium can stimulate parathyroid hormone (PTH) release which may then increase bone resorption, enhance renal calcium reabsorption, and stimulate renal conversion of hydroxyvitamin D3, to the active moiety 1,dihydroxyvitamin D3 [1,25(OH)2D3] which then will enhance intestinal calcium absorption.

These mechanisms restore the serum calcium to Cited by: 6. Age-related muscle loss. Lean muscle mass generally contributes up to about 50% of total bodyweight in young adults, but decreases with age to be about 25% of total bodyweight by age 75–80 years.

15 Declining muscle mass in the lower extremities with ageing is most significant to mobility status, and the cross-sectional area of the vastus lateralis (quadriceps) muscle Cited by: Ahlgren JD () Epidemiology and risk factors in pancreatic cancer. Semin Oncol Beck SA () Inhibition of tumour-induced lipolysis in vitro and cachexia and tumour growth in vivo by eicosapentaenoic acid.

Maingay JP, Ross JA () Down-regulation of the acute-phase response in patients with pancreatic cancer cachexia Cited by: 7.

Factors determining inadequate hypoglycaemia during insulin tolerance testing (ITT) after pituitary surgery. Clin Endocrinol (Oxf). ;71(1) Pfeifer M, Kanc K, Verhovec R, Kocijancic A. Reproducibility of the insulin tolerance test (ITT) for assessment of growth hormone and cortisol secretion in normal and hypopituitary adult men.

Full text of "Muir S Textbook Of Pathology Tenth Edition" See other formats. JNCI J Natl Cancer Inst Tisdale 73(1) - Free download as PDF File .pdf), Text File .txt) or read online for free.

review. Deterioration of nutritional state and persistent weight loss may have deleterious consequences for cancer patients. The prevalence of cancer-related malnutrition ranges from 74% in in- and out-patients, and is related to an increased risk of adverse clinical outcome 1, 7, poor quality of life, and lower survival rates addition, as many as 20% of cancer patients die from the.


This book aims to conceptualise the fact that cachexia is a clinical syndrome that accompanies the course of several medical conditions such as cancer, heart failure, diabetes, chronic renal failure and chronic obstructive lung disease, as well as gastrointestinal and infection-related diseases (e.g.

HIV infection and sepsis) and ageing. Growth Factors and their Receptors in Cancer Metastasis Cancer Metastasis – Biology and Treatment VOLUME 2 Series Editors Richard J. Ablin, Innapharma, Inc., Parkridge, U.S.A.

Wen G. Jiang, University of Wales College of Medicine, Cardiff, U.K. Catabolic states unrelated to cancer (e.g. infections or chronic heart failure).

Loss of muscle in the absence of cachexia and wasting due to decreased muscle. Cachexia is a separate condition in which the prominent clinical feature is weight loss, and muscle wasting is associated with severe illness that occurs much more rapidly than does age-related or disease-related muscle loss Muscle mass and strength are commonly decreased in patients with rheumatoid : In order to understand better the value of these complex interventions in cancer patients and try to identify potential factors that could mediate the effect across different diseases and settings, we carried out a literature review by retrieving and assessing eligible papers (in English, reporting results from controlled studies in advanced.

Leaders in Pharmaceutical Business Intelligence, launched in April an Open Access Online Scientific Journal is a scientific, medical and business multi expert authoring environment in several domains of life sciences, pharmaceutical, healthcare & medicine industries. Cai J, Jiang WG, Mansel RE.

“Inhibition of angiogenic factor- and tumour-induced angiogenesis by gamma linolenic acid.” Prostaglandins Leukot Essent Fatty Acids. (): Cain K, Bratton SB, Cohen GM.

“The Apaf-1 apoptosome: a large caspase-activating complex.” Biochimie. (): Chamberlain MC, Johnston SK. Paraneoplastic neurological syndromes.

PubMed Central. Leypoldt, F; Wandinger, K-P. Paraneoplastic neurological syndromes are immune-mediated erroneous attacks on the.